Microwave and Quantum Magnetics

Contains reports on two research projects.National Institutes of Health (Grant 5 PO1 CA31303

GALEX Observations of CS and OH Emission in Comet 9P/Tempel 1 During Deep Impact

GALEX observations of comet 9P/Tempel 1 using the near ultraviolet (NUV) objective grism were made before, during and after the Deep Impact event that occurred on 2005 July 4 at 05:52:03 UT when a 370 kg NASA spacecraft was maneuvered into the path of the comet. The NUV channel provides usable spectral information in a bandpass covering 2000 - 3400 A with a point source spectral resolving power of approximately 100. The primary spectral features in this range include solar continuum scattered from cometary dust and emissions from OH and CS molecular bands centered near 3085 and 2575 A, respectively. In particular, we report the only cometary CS emission detected during this event. The observations allow the evolution of these spectral features to be tracked over the period of the encounter. In general, the NUV emissions observed from Tempel 1 are much fainter than those that have been observed by GALEX from other comets. However, it is possible to derive production rates for the parent molecules of the species detected by GALEX in Tempel 1 and to determine the number of these molecules liberated by the impact. The derived quiescent production rates are Q(H2O) = 6.4e27 molecules/s and Q(CS2) = 6.7e24 molecules/s, while the impact produced an additional 1.6e32 H2O molecules and 1.3e29 CS2 molecules, a similar ratio as in quiescent outgassing.Comment: 15 pages, 4 figures, accepted for publication in the Astrophysical Journa

Production, Outflow, Velocity, and Radial Distribution of H2O and OH in the Coma of Comet C/1995 O1 (Hale-Bopp) from Wide-field Imaging of OH

Observations of OH are a useful proxy of the water production rate (Q H2O) and outflow velocity (VH2O) in comets. From wide-field images taken on 1997 March 28 and April 8 that capture the entire scale length of the OH coma of comet C/1995 O1 (Hale-Bopp), we obtain Q OH from the model-independent method of aperture summation and Q H2O from the OH photochemical branching ratio, BROH. Using an adaptive ring summation algorithm, we extract the radial brightness distribution of OH 0-0 band emission out to cometocentric distances of up to 10 to the sixth power km, both as azimuthal averages and in quadrants covering different position angles relative to the comet-Sun line. These profiles are fitted using both fixed and variable velocity two-component spherical expansion models to estimate VOH with increasing distance from the nucleus. The OH coma of Hale-Bopp was more spatially extended than those of previous comets, and this extension is best matched by a variable acceleration of H 2O and OH that acted across the entire coma, but was strongest within 1-2 × 104 km from the nucleus. Our models indicate that VOH at the edge of our detectable field of view (10 to the sixth power km) was ∼2-3 times greater in Hale-Bopp than for 1P/Halley class comet at 1 AU, which is consistent with the results of more sophisticated gas-kinetic models, extrapolation from previous observations of OH in comets with QH2O \u3e 10 to the twenty-ninth power s superscript -1, and direct radio measurements of the outer coma Hale-Bopp OH velocity. The likely source of this acceleration is thermalization of the excess energy of dissociation of H2O and OH over an extended collisional coma. When the coma is broken down by quadrants in position angle, we find an azimuthal asymmetry in the radial distribution that is characterized by an increase in the spatial extent of OH in the region between the orbit-trailing and anti-Sunward directions. Model fits specific to this area and comparison with radio OH measurements suggest greater acceleration here, with VOH ∼ 1.5 times greater at a 10 to the sixth power km cometocentric distance than elsewhere in the coma. We discuss several mechanisms that may have acted within the coma to produce the observed effect

Procalcitonin guided antibiotic therapy and hospitalization in patients with lower respiratory tract infections: a prospective, multicenter, randomized controlled trial

<p>Abstract</p> <p>Background:</p> <p>Lower respiratory tract infections like acute bronchitis, exacerbated chronic obstructive pulmonary disease and community-acquired pneumonia are often unnecessarily treated with antibiotics, mainly because of physicians' difficulties to distinguish viral from bacterial cause and to estimate disease-severity. The goal of this trial is to compare medical outcomes, use of antibiotics and hospital resources in a strategy based on enforced evidence-based guidelines versus procalcitonin guided antibiotic therapy in patients with lower respiratory tract infections.</p> <p>Methods and design:</p> <p>We describe a prospective randomized controlled non-inferiority trial with an open intervention. We aim to randomize over a fixed recruitment period of 18 months a minimal number of 1002 patients from 6 hospitals in Switzerland. Patients must be >18 years of age with a lower respiratory tract infections <28 days of duration. Patients with no informed consent, not fluent in German, a previous hospital stay within 14 days, severe immunosuppression or chronic infection, intravenous drug use or a terminal condition are excluded. Randomization to either guidelines-enforced management or procalcitonin-guided antibiotic therapy is stratified by centre and type of lower respiratory tract infections. During hospitalization, all patients are reassessed at days 3, 5, 7 and at the day of discharge. After 30 and 180 days, structured phone interviews by blinded medical students are conducted. Depending on the randomization allocation, initiation and discontinuation of antibiotics is encouraged or discouraged based on evidence-based guidelines or procalcitonin cut off ranges, respectively. The primary endpoint is the risk of combined disease-specific failure after 30 days. Secondary outcomes are antibiotic exposure, side effects from antibiotics, rate and duration of hospitalization, time to clinical stability, disease activity scores and cost effectiveness. The study hypothesis is that procalcitonin-guidance is non-inferior (i.e., at worst a 7.5% higher combined failure rate) to the management with enforced guidelines, but is associated with a reduced total antibiotic use and length of hospital stay.</p> <p>Discussion:</p> <p>Use of and prolonged exposure to antibiotics in lower respiratory tract infections is high. The proposed trial investigates whether procalcitonin-guidance may safely reduce antibiotic consumption along with reductions in hospitalization costs and antibiotic resistance. It will additionally generate insights for improved prognostic assessment of patients with lower respiratory tract infections.</p> <p>Trial registration:</p> <p>ISRCTN95122877</p

A polarity reversal in the large-scale magnetic field of the rapidly rotating Sun HD 190771

Aims. We investigate the long-term evolution of the large-scale photospheric magnetic field geometry of the solar-type star HD 190771. With fundamental parameters very close to those of the Sun except for a shorter rotation period of 8.8 d, HD 190771 provides us with a first insight into the specific impact of the rotation rate in the dynamo generation of magnetic fields in 1 $M_\odot$ stars. Methods. We use circularly polarized, high-resolution spectra obtained with the NARVAL spectropolarimeter (Observatoire du Pic du Midi, France) and compute cross-correlation line profiles with high signal-to-noise ratio to detect polarized Zeeman signatures. From three phase-resolved data sets collected during the summers of 2007, 2008, and 2009, we model the large-scale photospheric magnetic field of the star by means of Zeeman-Doppler imaging and follow its temporal evolution. Results. The comparison of the magnetic maps shows that a polarity reversal of the axisymmetric component of the large-scale magnetic field occurred between 2007 and 2008, this evolution being observed in both the poloidal and toroidal magnetic components. Between 2008 and 2009, another type of global evolution occured, characterized by a sharp decrease of the fraction of magnetic energy stored in the toroidal component. These changes were not accompanied by significant evolution in the total photospheric magnetic energy. Using our spectra to perform radial velocity measurements, we also detect a very low-mass stellar companion to HD 190771.Comment: Accepted by Astronomy and Astrophysics (Letter to the Editor